The Mast Cell Pathway to Inflammation and Homeostasis: Pharmacolo- gical Insights

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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The Mast Cell Pathway to Inflammation and Homeostasis: Pharmacolo- gical Insights

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 5(4): 323-334.

Author(s): S. Kakavas, E. Zampeli, K. Papamichael, B. Delitheos and E Tiligada.

Affiliation: Department of Experimental Pharmacology, Medical School, University of Athens, M. Asias 75, GR-11527 Athens, Greece.


Mast cells (MCs) were first described by Paul Ehrlich as well fed granular cells that stain metachromatically. Today MCs are regarded as multifunctional, granulated, tissue-dwelling cells distributed in the perivascular spaces and connective tissues of every major organ of the body. Their long recognized phenotypic diversity might be associated not only with their anatomic distribution and mediator repertoire, but also with their functional characteristics related to the regulation of effector pathways. In addition to their historical involvement in type I hypersensitivity response, MCs have emerged as versatile effector cells with functional diversity and homeostatic functions in non-IgE-mediated inflammatory responses, autoimmunity, bidirectional interactions with the neuroendocrine circuit, the urinary, gastrointestinal, cardiovascular and endocrine systems, in metabolism and malignancy. Thus, MCs appear to receive, integrate and transmit a wide range of signals in their microenvironment, coordinated by the differential release of their pro-inflammatory and anti-inflammatory granular mediators. Understanding the heterogeneity of this complex cellular communication may provide a tool for selective pharmacological intervention directed to specific MC subsets.


Allergy, heterogeneity, homeostasis, inflammation, immunity, mast cell, neuroendocrine.

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Article Details

Volume: 5
Issue Number: 4
First Page: 323
Last Page: 334
Page Count: 12
DOI: 10.2174/187152306778772793
Price: $58

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