Interleukin-26, An Epitheliotropic T-Cell Cytokine

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Interleukin-26, An Epitheliotropic T-Cell Cytokine



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 5(3): 275-277.

Author(s): Oliver Braum, Heide Pirzer and Helmut Fickenscher.

Affiliation: Institute for Infection Medicine, Christian Albrechts University of Kiel, Brunswiker Str. 4, 24105 Kiel, Germany.

Abstract

Interleukin-26 (IL-26) belongs to the family of cellular cytokines which share sequence homology with IL-10, however, without functional conservation. The il-26 gene is situated on the human chromosome 12q15 in close neighbourhood to the genes for the related T-cellular cytokines interferon-γ (IFN-γ) and IL-22. il-26 was discovered due to its overexpression in T cells after growth transformation with herpesvirus saimiri. IL-26 is produced by activated T cells, forms homodimers, and acts on epithelial target cells such as colon carcinoma cells or keratinocytes. Presumably due to its positive net charge, IL-26 adheres to glycosaminoglycans on cell surfaces. Stimulation with IL-26 results in the phosphorylation and activation of the transcription factors STAT1 and STAT3 and in the induction of CD54 surface expression and secretion of cytokines such as IL-8 and IL-10. These effects are mediated by an IL-26-specific receptor complex consisting of IL-20R1 and IL-10R2. Thus, IL-26 appears to be a rather proinflammatory and cell-surface associated cytokine linking local T-cell activation with epithelial functions.

Keywords:

AK155, colon carcinoma, ICAM-1, Interleukin-26, IL-26, herpesvirus saimiri, STAT, T cell.



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Article Details

Volume: 5
Issue Number: 3
First Page: 275
Last Page: 277
Page Count: 3
DOI: 10.2174/187152306778017674
Price: $58
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