Interleukin 20

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 16, 3 Issues, 2017


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Interleukin 20



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 5(3): 243-250.

Author(s): B. E. Rich and T S Kupper.

Affiliation: Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Abstract

IL-20 is a member of the IL-10 family of cytokines that also includes IL-10, IL-19, IL-22, IL-24, and IL-26 as well as a number of viral homologs. Keratinocytes and monocytes in states of activation can produce IL-20. It transmits signals via two different cell-surface receptor complexes resulting in the activation of STAT3 in keratinocytes and other epithelial cells. Thus it appears to be primarily an inducible autocrine and paracrine factor that regulates proliferation and differentiation of keratinocytes in the context of inflammation. Several findings indicate that IL-20 mediates the hyperproliferation of keratinocytes associated with cutaneous inflammation. As such it is likely to have a central role in inflammatory skin diseases such as psoriasis and eczema. IL-20 also promotes the expansion of multipotential hematopoietic progenitor cells indicating a role beyond the response of epithelial cells to inflammation. Increased understanding of the biology of IL-20 may provide novel opportunities for diagnostic methods and therapeutic intervention.

Keywords:

Interleukin-20, IL-20, epidermis, keratinocyte, inflammation, psoriasis, eczema.



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Article Details

Volume: 5
Issue Number: 3
First Page: 243
Last Page: 250
Page Count: 8
DOI: 10.2174/187152306778017683
Price: $58
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