Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 5(2): 189-203.

Author(s): Victoria Magrioti and George Kokotos.

Affiliation: Laboratory of OrganicChemistry, Department of Chemistry, University of Athens, Panepistimiopolis,15771 Athens, Greece.

Abstract

PLA2 is an important signaling enzyme that generates multiple downstream effectors, such as arachidonic acid and PAF, which are key mediators of inflammation as well as other pathophysiological conditions. Inhibition of PLA2 is potentially an effective therapy for several inflammatory diseases. In this review, we discuss the various classes of synthetic inhibitors of Group IVA and Group VIA phospholipase A2.

Keywords:

Analgesic, anti-inflammatory agents, inflammation, inhibitors, 2-oxoamide, pain, phospholipase A2, trifluoromethyl ketone.



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Article Details

Volume: 5
Issue Number: 2
First Page: 189
Last Page: 203
Page Count: 15
DOI: 10.2174/187152306776872451
Price: $58
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