Vascular Reactions of Iodinated X-Ray Contrast Media: Mechanisms and Possible Therapeutic Interventions

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Vascular Reactions of Iodinated X-Ray Contrast Media: Mechanisms and Possible Therapeutic Interventions



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 5(2): 129-137.

Author(s): Michael Uder and Marc Heinrich.

Affiliation: Department of diagnosticRadiology, University Hospital, Maximiliansplatz 1, 91054 Erlangen,Germany.

Abstract

Vascular reactions after administration of all classes of iodinated x-ray contrast media are well known side effects of these drugs. Both vasodilation and vasoconstriction have been observed. The manner and extent of the change in vessel tone depends on the type of contrast medium, species, vascular territory and contractile state of the vessels. The mechanisms underlying the vascular reaction induced by contrast media are currently not completely clear and studies on this question are partly contradictory or non-conclusive. Even if these side effects do not vitally compromise the patients, they are mainly responsible for patients discomfort during examinations. To date, there are only a few possibilities to treat this type of side effect. In this review we describe the effects of high osmolar ionic, low osmolar non-ionic and isotonic contrast media on different vascular beds in humans and animals. Data from clinical and in vivo studies as well as from in vitro investigations on isolated organs and isolated vessel segments will be discussed. It will give an overview of the mechanistic explanations of the vascular reactions.

Keywords:

Contrast media, vasodilation, vasoconstriction, pulmonary circulation, renal circulation, coronary circulation, vascular smooth muscle, endothelium.



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Article Details

Volume: 5
Issue Number: 2
First Page: 129
Last Page: 137
Page Count: 9
DOI: 10.2174/187152306776872497
Price: $58
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