Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Thalidomide and Analogs as Anti-Inflammatory and Immunomodulator Drug Candidates



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 5(1): 79-95.

Author(s): Lidia M. Lima, Carlos A. Manssour Fraga, Vera L. Goncalves Koatz and Eliezer J Barreiro.

Affiliation: Laboratorio de Avaliacao eSíntese de Substancias Bioativas (LASSBio), CP 68.006, 21944-190, Rio deJaneiro, RJ, Brazil), Faculdade de Farmacia, Universidade Federal do Rio deJaneiro, RJ, Brazil.

Abstract

Thalidomide ([2-(2,6-dioxo-hexahydro-3-(R,S)-pyridinyl)-1,3-isoindolinedione]), well known by its teratogenic effect, caused birth defects in up to 12,000 children in the 1960s. More recently, this drug was approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum, under restricted-use program, and a variety of new possible therapeutic applications have been described. This article will accomplish a review of medicinal chemistry aspects of thalidomide and state of the art in the development of new anti-inflammatory and immunomodulator drug candidates designed using thalidomide as lead-compound.

Keywords:

CYP450, Teratogenicity, bioactivation, thiothalidomide analogs, CoMFA, cAMP.



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Article Details

Volume: 5
Issue Number: 1
First Page: 79
Last Page: 95
Page Count: 17
DOI: 10.2174/187152306775537328
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