Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 14(1): 35-46.

Author(s): Prasanna A. Datar and Saleel A Limaye.

Affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune – 411041, Maharashtra, India.

Abstract

Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

Keywords:

Analgesic activity, Mannich bases, N1-substituted benzimidazoles.



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Article Details

Volume: 14
Issue Number: 1
First Page: 35
Last Page: 46
Page Count: 12
DOI: 10.2174/1871523014666150312164625
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