Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

Download PDF Flyer

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

Claudiu T. Supuran
Neurofarba Department
University of Florence

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Rational Design and Synthesis of Benzamides as Non-ulcerogenic Anti-inflammatory Agents

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 13(3): 174-187.

Author(s): Saurabh Khadse, Vinod Ugale and Gokul Talele.

Affiliation: Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Shirpur (Dhule), Maharashtra, India.


In an attempt to find a new class of anti-inflammatory agents, a series of novel benzamides 3 (ab1-ab16) was synthesized by utilizing some arylideneoxazolones 2(az1-az4) having 2-acetyloxyphenyl substitution on their second position. IR, 1H-NMR, 13C NMR and HRMS, confirmed the structures of these synthesized compounds. Among the tested benzamide compounds 3ab1, 3ab2, 3ab11 and 3ab16 showed promising anti-inflammatory activity with lessened propensity to cause gastro-intestinal hypermotility and ulceration when compared with standard Indomethacin. Virtual screening was performed by docking the designed compounds into the ATP binding site of COX-2 receptor to predict if these compounds have analogous binding mode to the COX-2 inhibitor.


Anti-inflammatory, benzamides, docking, gastro-intestinal hypermotility, ulcerogenic activity.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 13
Issue Number: 3
First Page: 174
Last Page: 187
Page Count: 14
DOI: 10.2174/1871523013666141017102257
Price: $58

Related Journals

Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science