MicroRNA: Novel Modulators of the Cholinergic Anti-Inflammatory Pathway

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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MicroRNA: Novel Modulators of the Cholinergic Anti-Inflammatory Pathway



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 12(2): 136-140.

Author(s): Medha Priyadarshini, N.A. Arivarasu, Aaliya Shah, Shams Tabrez, Shubha Priyamvada and Mohd Aatif.

Affiliation: Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P., India.

Abstract

MicroRNAs (miRNAs) have emerged as key gene regulators controlling the expression of many target mRNAs. The nervous system harbors highest number of miRNAs expressed in a spatially and temporally controlled manner. Neural miRNAs have been accredited with diverse roles like regulation of neural differentiation, synaptogenesis, inflammation, memory and cognition. Their aberrant expression and/or function has been linked to various neurodegenerative, neuroinflammatory and stress related disorders. Recent evidence indicates that miRNAs are essential to the fine tuning of the immune responses. Besides controlling the maturation, proliferation and differentiation of myeloid and lymphoid lineages they participate directly by modulating the signaling pathways through the Toll-like receptors and thus the cytokine response. The miRNAs commuting between the nervous and immune systems and affecting the neuro-immune dialogue are emerging.

Keywords:

Acetylcholinestrase, α7 acetylcholine receptor, cholinergic anti-inflammatory pathway, microRNA, miR-132, vagus nerve.



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Article Details

Volume: 12
Issue Number: 2
First Page: 136
Last Page: 140
Page Count: 5
DOI: 10.2174/1871523011312020005
Price: $58
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