Cholinergic Drugs as Therapeutic Tools in Inflammatory Diseases: Participation of Neuronal and Non-Neuronal Cholinergic Systems.

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Cholinergic Drugs as Therapeutic Tools in Inflammatory Diseases: Participation of Neuronal and Non-Neuronal Cholinergic Systems.



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 12(2): 109-116.

Author(s): María Elena Sales.

Affiliation: Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET. Segunda Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires. Paraguay 2155 piso 16 sector izq. Buenos Aires. Argentina, CABA, CP 1121.

Abstract

Acetylcholine (ACh) is synthesized by choline acetyltransferase (ChAT) from acetylcoenzime A and choline. This reaction occurs not only in pre-ganglionic fibers of the autonomic nervous system and post-ganglionic parasympathetic nervous fibers but also in non neuronal cells. This knowledge led to expand the role of ACh as a neurotransmitter and to consider it as a “cytotransmitter” and also to evaluate the existence of a non-neuronal cholinergic system comprising ACh, ChAT, acetylcholinesterase, and the nicotinic and muscarinic ACh receptors, outside the nervous system. This review analyzes the participation of cholinergic system in inflammation and discusses the role of different muscarinic and nicotinic drugs that are being used to treat skin inflammatory disorders, asthma, and chronic obstructive pulmonary disease as well as, intestinal inflammation and systemic inflammatory diseases, among others, to assess the potential application of these compounds as therapeutic tools.

Keywords:

acetylcholine, muscarinic receptors-nicotinic receptors-cholinergic drugs, atopic dermatitis-chronic obstructive pulmonary disease, intestinal inflammation, sepsis.



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Article Details

Volume: 12
Issue Number: 2
First Page: 109
Last Page: 116
Page Count: 8
DOI: 10.2174/1871523011312020002
Price: $58
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