New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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New Insights in Research About Acute Ischemic Myocardial Injury and Inflammation



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 12(1): 47-54.

Author(s): Anne Vincent, Benoit Lattuca, Nolwenn Merlet, Catherine Sportouch-Dukhan and Stephanie Barrere-Lemaire.

Affiliation: 141, rue de la Cardonille - 34094 Montpellier Cedex 5 - France.

Abstract

Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.

Keywords:

Inflammation, myocardial injury, ischemia-reperfusion.



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Article Details

Volume: 12
Issue Number: 1
First Page: 47
Last Page: 54
Page Count: 8
DOI: 10.2174/1871523011312010007
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