Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 12(1): 24-35.

Author(s): Nolwenn Merlet, David Busseuil, Eric Rheaume and Jean-Claude Tardif.

Affiliation: Montreal Heart Institute, Research Center, 5000 Bélanger Est, Montréal, QC, Canada (H1T 1C8).

Abstract

Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.

Keywords:

Glucocorticoids, NSAIDs, biologics, heart failure, ischemia/reperfusion, cardiac hypertrophy, cardiotoxic drugs, experimental models.



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Article Details

Volume: 12
Issue Number: 1
First Page: 24
Last Page: 35
Page Count: 12
DOI: 10.2174/1871523011312010005
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