Colchicine: An Old Wine in a New Bottle?

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Colchicine: An Old Wine in a New Bottle?



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 12(1): 14-23.

Author(s): Francois Roubille, Ekaterini Kritikou, David Busseuil, Stephanie Barrere-Lemaire and Jean-Claude Tardif.

Affiliation: Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada.

Abstract

Although colchicine, a natural product, is one of the oldest drugs still currently available, its possible functions seem to be surprisingly not well-known. Beyond its present medicinal use (gout, familial Mediterranean fever, Behcet’s disease, chondrocalcinosis and other crystal arthritis), numerous other conditions have been recently proposed for the use of this drug, including pericardial diseases. However, colchicine appears as a double-edged sword, with underestimated toxicity and frequent side effects. In this review, we present the main pharmacologic features of this drug, with an emphasis on toxicity and highlight its possible applications in the cardiovascular field.

Keywords:

Colchicine, pericardial diseases, pericarditis, gout, tubulin, inflammation, cardiovascular diseases.



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Article Details

Volume: 12
Issue Number: 1
First Page: 14
Last Page: 23
Page Count: 10
DOI: 10.2174/1871523011312010004
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