A New Method for a Quantitative Determination of Piroxicam in Pharmaceutical Formulations Using FT-IR Spectrometry

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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A New Method for a Quantitative Determination of Piroxicam in Pharmaceutical Formulations Using FT-IR Spectrometry



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(3): 262-266.

Author(s): Andrei A. Bunaciu, Serban Fleschin and Hassan Y Aboul-Enein.

Affiliation: Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, Tahrir Street, Dokki, Cairo 12311, Egypt.

Abstract

A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can be determined by various methods and now we are adding a new one that uses a Fourier transform infrared spectrophotometric technique. Conventional spectra were compared for best determination of active substance in pharmaceutical formulations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.

Keywords:

FT-IR analysis, piroxicam, chemometric methods, drug analysis.



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Article Details

Volume: 11
Issue Number: 3
First Page: 262
Last Page: 266
Page Count: 5
DOI: 10.2174/1871523011202030262
Price: $58
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