Multiple Roles of Histamine in Autoimmune Demyelinating Disease of the Central Nervous System

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 15, 3 Issues, 2016

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Multiple Roles of Histamine in Autoimmune Demyelinating Disease of the Central Nervous System

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 10(6): 418-426.

Author(s): Massimo Costanza, Silvia Musio and Rosetta Pedotti.

Affiliation: Neuroimmunology and Neuromuscular Disorders Unit, Foundation IRCCS Neurological Institute C. Besta, Via Amadeo, 42; 20133 Milan, Italy.


Histamine is a biogenic amine with a broad spectrum of activities in various physiological and pathological conditions. Beside its well characterized effects in allergic responses and acute inflammation, histamine modulates the cytokine network, influencing T helper 1 and T helper 2 balance and antibody isotype. In multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), there are several steps in the autoimmune attack against myelin of the central nervous system where histamine has been shown to play important roles. In this review, we summarize the evidences supporting the hypothesis of a significant contribution for histamine in autoimmune demyelinating diseases of the central nervous system. A deeper appreciation of the mechanisms by which histamine regulates the development of EAE and MS might have relevance in the therapy of these diseases.


Blood-brain barrier, cytokines, experimental autoimmune encephalomyelitis, histamine, multiple sclerosis, T cells, central nervous system, Interleukin, Histamine receptor, PHARMACOLOGICAL STUDIES.

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Article Details

Volume: 10
Issue Number: 6
First Page: 418
Last Page: 426
Page Count: 9
DOI: 10.2174/1871523011109060418
Price: $58

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