Novel Piperazinyl Derivatives with Anti-Hyperalgesic, Anti-Allodynic and Anti-Inflammatory activities Useful for the Treatment of Neuropathic Pain

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Novel Piperazinyl Derivatives with Anti-Hyperalgesic, Anti-Allodynic and Anti-Inflammatory activities Useful for the Treatment of Neuropathic Pain



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(2): 182-190.

Author(s): Monika Sharma, Shraddha Suman Dash, Gangadhar Matharasala, Vanamala Deekshith, Dharmarajan Sriram and Perumal Yogeeswari.

Affiliation: Neuropathic Pain Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, R.R. District-500078, Andhra Pradesh, India.

Abstract

A series of structurally novel compounds possessing 2-phenylpiperazin-1-yl nicotinamide template was synthesized and evaluated for neuropathic pain activity. After the assessment of neurotoxicity and peripheral analgesic activity, the compounds were evaluated in a peripheral neuropathic pain model, the chronic constriction injury (CCI) to assess their antiallodynic and antihyperalgesic potential. Studies carried out to assess the underlying mechanism revealed that the compounds (5 and 6) suppressed the inflammatory component of the neuropathic pain and inhibited oxidative and nitrosative stress.

Keywords:

Neuropathic pain, antiallodynic, antihyperalgesic, carrageenan, nitric oxide, DPPH.



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Article Details

Volume: 11
Issue Number: 2
First Page: 182
Last Page: 190
Page Count: 9
DOI: 10.2174/187152312803305704
Price: $58
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