Application of Small Molecules/Macromolecules in Ocular Inflammatory Diseases

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


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Application of Small Molecules/Macromolecules in Ocular Inflammatory Diseases



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(2): 113-120.

Author(s): Baoying Liu, Chi-Chao Chan and Robert B Nussenblatt.

Affiliation: Laboratory of Immunology National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Macrobiomolecular treatments for ocular inflammatory diseases have been described in a previous review. This article mainly discusses the application of small molecules in uveitis therapy, which includes corticosteroids, salicylic acid (aspirin), metabolite analogs, and anti-oxidative agents. Additionally, we update recent advances in peptide and nucleic acid related therapies, and focus mainly on the calcineurin inhibitor, cyclosporine, oral tolerant retinal proteins/peptides, gene therapy and ribonucleic acid interference strategies. We classify these immunomodulatory agents by their molecular signatures and highlight the molecular structure and mechanisms of function. These developments in understanding molecular mechanisms of the diseases, with the advent of new technologies, advance current therapeutic approaches. The future direction is to tailor treatments to individual patients in order to provide the safest and most effective therapies for ocular inflammatory diseases.

Keywords:

Uveitis, macrobiomolecule, small molecule, immunosuppresion, anti-inflammation.



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Article Details

Volume: 11
Issue Number: 2
First Page: 113
Last Page: 120
Page Count: 8
DOI: 10.2174/187152312803305713
Price: $58
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