Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)


Volume 15, 3 Issues, 2016


Download PDF Flyer




Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Claudiu T. Supuran
Neurofarba Department
University of Florence
Florence
Italy


View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review



Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(1): 96-112.

Author(s): Giuseppe Carlucci, Maura Carlucci and Marcello Locatelli.

Affiliation: Universita degli Studi “G. d’Annunzio” Chieti-Pescara – Dipartimento di Farmacia – via dei Vestini – 66100 Chieti- Italy.

Abstract

The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory drugs is included.

Keywords:

NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules.



Download Free Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 11
Issue Number: 1
First Page: 96
Last Page: 112
Page Count: 17
DOI: 10.2174/187152312803476228
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science