Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review

ISSN: 1875-614X (Online)
ISSN: 1871-5230 (Print)

Volume 16, 3 Issues, 2017

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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents

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Claudiu T. Supuran
Neurofarba Department
University of Florence

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Analysis of Anti-Inflammatory Enantiomers by HPLC in Human Plasma and Urine: A Review

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 11(1): 96-112.

Author(s): Giuseppe Carlucci, Maura Carlucci and Marcello Locatelli.

Affiliation: Universita degli Studi “G. d’Annunzio” Chieti-Pescara – Dipartimento di Farmacia – via dei Vestini – 66100 Chieti- Italy.


The analysis of drugs in various biological fluids is an important criterion for the determination of the physiological performance of a drug. NSAIDs are non-selective inhibitors of prostaglandin biosynthesis and indicated for the acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis. This paper reviews the recent developments in bioanalysis of these drugs. In particular, sample preparation end, handling procedures, chromatographic conditions and detection methods are discussed. A summary of published HPLC assays for individual antiinflammatory drugs is included.


NSAIDs, enantiomers, biological fluids, HPLC, prostaglandin biosynthesis, antipyretic drugs, antinflammatory drugs, Etodolac, Fenoprofen, carboxyibuprofen metabolites, non-selective inhibitors, rheumatoid arthritis, osteoarthritis, HPLC assays, pharmacokinetics, chiral drug molecules.

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Article Details

Volume: 11
Issue Number: 1
First Page: 96
Last Page: 112
Page Count: 17
DOI: 10.2174/187152312803476228

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