Potential of Selected Antioxidants for Influenza Chemotherapy

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 14, 2 Issues, 2016

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Potential of Selected Antioxidants for Influenza Chemotherapy

Anti-Infective Agents, 7(2): 73-83.

Author(s): Noboru Uchide and Hiroo Toyoda.

Affiliation: Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.


The human beings face the threat of a highly pathogenic avian influenza virus. The use of anti-influenza drugs is receiving much greater attention to playing an important role as a first-line defense against a new pandemic of influenza virus infection. However, influenza viruses resistant to currently available anti-influenza drugs, such as the M2 proton channel inhibitors and the neuraminidase inhibitors, are emerged frequently during the treatment with drugs. This suggests the need for development of new anti-influenza drugs utilizing alternative antiviral mechanisms and consideration of using anti-influenza drug combinations. Recent studies have clarified that the pathogenesis of influenza virus infection involves not only the virus replication-associated apoptotic cell death in the infected cells, but also the injury of noninfected cells by reactive oxygen species derived from macrophages and neutrophils infiltrated into the virus-infected organs. These findings provide a possibility that an agent with all of the following antiviral, anti-apoptosis and antioxidant activities can be a drug of choice for the treatment of patients with influenza virus infection. Selected antioxidants, such as pyrrolidine dithiocarbamate, N-acetyl-L-cysteine, glutathione, nordihydroguaiaretic acid and thujaplicin, possessed all of these activities. The combination of antioxidants, such as superoxide dismutase and N-acetyl-L-cysteine, with antiviral drug ribavirin synergistically reduced the lethal effect of influenza virus infection. Accumulating number of evidence highlights a potential of selected antioxidants for influenza chemotherapy and a possibility that combination of antioxidants with current anti-influenza drugs can improve usual influenza chemotherapy.


Influenza virus, antioxidants, apoptosis, macrophage, monocyte differentiation-inducing (MDI) factors, phagocytosis, reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, reactive oxygen species.

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Article Details

Volume: 7
Issue Number: 2
First Page: 73
Last Page: 83
Page Count: 11
DOI: 10.2174/187152108783954605
Price: $58
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