Antisense DNA and RNA: Potential Therapeutics for Viral Infection

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 14, 2 Issues, 2016

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Antisense DNA and RNA: Potential Therapeutics for Viral Infection

Anti-Infective Agents, 5(4): 367-377.

Author(s): Ji Yuan, Travis Lim, Zhen Liu, Dexin Qiu, Brian Wong, Honglin Luo, Xiaoning Si, Bruce McManus and Decheng Yang.

Affiliation: Cardiovascular Research Laboratory, University of British Columbia, St. Paul's Hospital, 1081 Burrard treet, Vancouver, B.C. Canada V6Z 1Y6.


Antisense DNA and RNA are valuable tools to inhibit expression of a target gene in a sequence-specific manner. These molecules are not only widely used for gene functional study but also for therapeutic purpose. The strategy for therapeutics is attributed to its specific inhibition of gene expression of pathogens or disease-causing genes. Three types of anti-mRNA strategies can be distinguished, including antisense oligodeoxynucleotide (AODN), nucleic acid enzymes, and double-stranded small interfering RNA (siRNA). In this article we overview the basic principles of AODN and siRNA and then focus on their potential applications in antiviral therapy including our own data on coxsackieviral infection, a common pathogen of human myocarditis. In addition, we also briefly discuss the problems and difficulties in these drug developments, which need to be overcome to achieve the final goal in clinical application.


Antisense oligodeoxynucleotide, small interfering RNA, antiviral agents, coxsackievirus B3.

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Article Details

Volume: 5
Issue Number: 4
First Page: 367
Last Page: 377
Page Count: 11
DOI: 10.2174/187152106778520460
Price: $58
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