Synthesis and Evaluation of Heterocyclic Scaffold-Based Styrene Conjugates as New Antibacterial Agents

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 14, 2 Issues, 2016

Download PDF Flyer

Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Synthesis and Evaluation of Heterocyclic Scaffold-Based Styrene Conjugates as New Antibacterial Agents

Anti-Infective Agents, 12(2): 198-205.

Author(s): M. Rudrapal, T. Mariya Babu, T. Ravi Chandra, U. Divya Durga, V. Swathi, B. Usha Naga Chandrika and K Ravishankar.

Affiliation: Aditya Institute of Pharmaceutical Sciences and Research, Surampalem, E.G. Dist., Andhra Pradesh - 533 437, India.


The conjugation of different substituted styryl (-CH=CH-Aryl) moieties with the biologically relevant heteroaromatic scaffolds such as 4-benzylidene-2-methyloxazol-5-one, 3-methyl-1-phenylpyrazol-5-one, 2-methylbenzimidazole, 6-methyluracil afforded the newer series (four different series, 1A-3C, 2A-C, 3A-C & 4A-C) of styrene derivatives. Newer styrene derivatives were synthesized and characterized by IR, NMR (1H & 13C), Mass spectroscopic/spectrometric methods and elemental analysis. Results of the antibacterial activity study reveal that the synthesized compounds possess in-vitro activity against the tested bacterial strains, which, however, was comparatively very less than that of the standard drug, amikacin sulphate. From the structure-activity relationship study, it could be attributed that the overall antibacterial efficacy of the conjugated series of styrene derivatives is the sum of bio-effectiveness of styryl moieties and heterocyclic scaffolds.


Antibacterial, benzimidazole, oxazole, pyrazole, styryl, uracil.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 12
Issue Number: 2
First Page: 198
Last Page: 205
Page Count: 8
DOI: 10.2174/2211352512666140715165318
Price: $58
Superbugs USA

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science