N-Thiolated β-Lactams

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 14, 2 Issues, 2016

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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N-Thiolated β-Lactams

Anti-Infective Agents, 1(3): 251-268.

Author(s): T. E. Long and E Turos.

Affiliation: Department of Chemistry, 4202 E. Fowler Avenue, University of South Florida, Tampa, FL 33620 USA


N-Thiolated β-lactams are β-lactam compounds that have a sulfur substituent on the nitrogen center. They represent a broad and growing family of bioactive molecules. In this review we provide a summary of the known biological properties of the different classes of N-thiolated β-lactams, and the methods used to prepare them. Our discussion begins with the N-sulfonic acid derivatives, which include the well-known monobactam family of antibiotics, followed by the N-sulfonyl, N-sulfinyl, and N-sulfenyl β-lactams.


n-thiolated beta lactams, monobactam compounds, sulfony1 beta lactam.

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Article Details

Volume: 1
Issue Number: 3
First Page: 251
Last Page: 268
Page Count: 18
DOI: 10.2174/1568012023354820
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