Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 15, 2 Issues, 2017


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Synthesis and Anti-tubercular Activities of Benzo[4,5]furo[2,3-c] Chromen -6-one Derivatives



Anti-Infective Agents, 10(1): 6-14.

Author(s): Noopur Srivastava, K. S. Anil Kumar, Sudhir Sinha, Ranjana Srivastava and D K Dikshit.

Affiliation: Medicinal & Process Chemistry Division, India.

Abstract

Synthesis and in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv of a number of 3-hydroxy[2,3-c][1]benzopyran-6(H)-ones 1a-f and 3-Benzyl-8-hydroxy-1,2,3,4-tetrahydro-chromeno[3,4- c]pyridin-5-ones 8a-c has been reported. Few of the compounds exhibited anti–tubercular activity with MIC as low as 3.12 μg/ml in virulent and avirulent strains.

Keywords:

BACTEC, Coumarin, MDR tuberculosis, pechman condensation, triarylmethanes, tuberculosis, BCG, Benzofurans, ANTI-TUBERCULAR ACTIVITY, DMAP.



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Article Details

Volume: 10
Issue Number: 1
First Page: 6
Last Page: 14
Page Count: 9
DOI: 10.2174/2211362611201010006
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