Anti-MRSA Cephems: An Update

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Anti-MRSA Cephems: An Update



Anti-Infective Agents, 1(3): 269-279.

Author(s): Dane M Springer.

Affiliation: Rib-X Pharmaceuticals, 300 George Street, New Haven, CT 06511, USA.

Abstract

A review of recent developments in the field of anti-MRSA cephems is presented. The R.W. Johnson / Microcide collaboration seems to be the most advanced effort to date, but many other companies are continuing their efforts to develop a cephalosporin for use against serious Gram-positive infections such as MRSA. A detailed account of the progression of the MRSA cephem program at Bristol-Myers Squibb is provided. This work produced a number of compounds that had excellent biological activity, and were safe in a murine model of acute toxicity.

Keywords:

anti-mrsa cephem, mrsa cephem.



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Article Details

Volume: 1
Issue Number: 3
First Page: 269
Last Page: 279
Page Count: 11
DOI: 10.2174/1568012023354929
Price: $58
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