A Review of Recent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Research Activity

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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A Review of Recent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Research Activity



Anti-Infective Agents, 1(2): 119-140.

Author(s): Jeffrey W Corbett.

Affiliation: Pharmacia Corporation, 301 Henrietta St., 7255-209-643, Kalamazoo, MI 49007, USA

Abstract

This non-nucleoside reverse transcriptase inhibitor review covers the patent and published literature from January, 1998-August, 2001. Major advances have been made in the past decade in discovering non-nucleoside reverse transcriptase inhibitors that are effective in inhibiting replication of wild-type virus. Attention is now focused upon the discovery of agents that are effective in inhibiting replication of virus with singly and doubly mutated HIV-1 reverse transcriptase. Notable advances in the discovery of such broad spectrum therapeutics are SG-153 and the quinazolines DPC961 and DPC083. Attempts at discovering other broad spectrum anti-viral agents are presented herein.

Keywords:

Hiv-1 non-nucleoside reverse transcriptase inhibitor, nnrti, stavudine.



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Article Details

Volume: 1
Issue Number: 2
First Page: 119
Last Page: 140
Page Count: 22
DOI: 10.2174/1568012023354938
Price: $58
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