Inhibitors of Mycothiol-S-Conjugate Amidase and Related Genes

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 15, 2 Issues, 2017


Download PDF Flyer




Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Inhibitors of Mycothiol-S-Conjugate Amidase and Related Genes



Anti-Infective Agents, 3(3): 221-231.

Author(s): G. M. Nicholas and C A Bewley.

Affiliation: Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892-0820, USA;

Abstract

Mycothiol is a small molecular weight thiol exclusive to actinomycetes, a subgroup of Gram-positive bacteria. Mycothiol is composed of one unit each of 1-D-glucosamine, 1-D-myo-inositol and N-acetyl cysteine. Novel enzymes involved in mycothiol biosynthesis, mycothiol-mediated detoxification, and mycothiol reduction have recently been identified, and several of these share little or no sequence homology to known mammalian enzymes. Together, these points suggest that targeting of mycothiol-associated biochemistry may be a valid approach to identifying new types of antibiotics specific to actinomycetes, which include the medically important mycobacteria. This review discusses mycothiol literature to date, with emphasis on chemical approaches to identifying and synthesizing inhibitors and chemical probes to study mycothiol biochemistry.

Keywords:

marine natural products, substrate-based inhibitors, mycobacterium tuberculosis, mycobacterium smegmatis, antituberculars, structural studies.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 3
Issue Number: 3
First Page: 221
Last Page: 231
Page Count: 11
DOI: 10.2174/1568012043353865
Price: $58
Advertisement
Global Biotechnology Congress 2017Drug Discovery and Therapy World Congress 2017

Related Journals




Related eBooks



Webmaster Contact: urooj@benthamscience.org Copyright © 2017 Bentham Science