Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*



Anti-Infective Agents, 4(2): 133-152.

Author(s): Wieslaw M. Kazmierski, Jennifer P. Peckham, Maosheng Duan, Terry P. Kenakin, Stephen Jenkinson, Kristjan S. Gudmundsson, Stephen C. Piscitelli and Paul L Feldman.

Affiliation: GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

Abstract

This review addresses key medicinal chemistry issues relevant in the discovery and development of CCR5 and CXCR4 antagonists as anti-HIV drugs. Recent progress in the discovery and development of such antagonists, SAR and clinical status are reviewed.

Keywords:

chemotherapy, transcriptase inhibitors, aids, ccr5 receptor, probe, chemokine, allosteric modulator.



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Article Details

Volume: 4
Issue Number: 2
First Page: 133
Last Page: 152
Page Count: 20
DOI: 10.2174/1568012053506981
Price: $58
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