Recent Progress in the Field of Antibacterial Pristinamycins

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 15, 2 Issues, 2017

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Recent Progress in the Field of Antibacterial Pristinamycins

Anti-Infective Agents, 4(3): 185-217.

Author(s): Eric Bacque, Jean-Claude Barriere and Nadine Berthaud.

Affiliation: Sanofi-Aventis Research Center:13 Quai J. Guesde, Vitry-sur-Seine, 94403 Cedex, France.


The design and optimisation of the second-generation antibacterial oral streptogramin is reported in terms of semi-synthesis, structure-activity relationships, pharmaco-kinetics properties and antibacterial activities. Our endeavours led to the selection of two new combinations RPR131166/RPR132493 (30/70) and RPR202868/RPR132552 (30/70) whose antibacterial properties will be reported in detail. The overall profile of the latter association, which is currently undergoing clinical development, suggests that it could be useful for the treatment of community-acquired infections.


antibacterial, streptogramins, pristinamycins, synergy, ribosome, structure-activity relationships, semi-synthesis.

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Article Details

Volume: 4
Issue Number: 3
First Page: 185
Last Page: 217
Page Count: 33
DOI: 10.2174/1568012054368128
Price: $58
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