Recent Progress in the Field of Antibacterial Pristinamycins

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 14, 2 Issues, 2016

Download PDF Flyer

Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

Aims & ScopeAbstracted/Indexed in

Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Recent Progress in the Field of Antibacterial Pristinamycins

Anti-Infective Agents, 4(3): 185-217.

Author(s): Eric Bacque, Jean-Claude Barriere and Nadine Berthaud.

Affiliation: Sanofi-Aventis Research Center:13 Quai J. Guesde, Vitry-sur-Seine, 94403 Cedex, France.


The design and optimisation of the second-generation antibacterial oral streptogramin is reported in terms of semi-synthesis, structure-activity relationships, pharmaco-kinetics properties and antibacterial activities. Our endeavours led to the selection of two new combinations RPR131166/RPR132493 (30/70) and RPR202868/RPR132552 (30/70) whose antibacterial properties will be reported in detail. The overall profile of the latter association, which is currently undergoing clinical development, suggests that it could be useful for the treatment of community-acquired infections.


antibacterial, streptogramins, pristinamycins, synergy, ribosome, structure-activity relationships, semi-synthesis.

Purchase Online Order Reprints Order Eprints Rights and Permissions

Article Details

Volume: 4
Issue Number: 3
First Page: 185
Last Page: 217
Page Count: 33
DOI: 10.2174/1568012054368128
Price: $58
Superbugs USA

Related Journals

Webmaster Contact: Copyright © 2016 Bentham Science