Polyfunctional Antibiotics Affecting Bacterial Membrane Dynamics

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


Download PDF Flyer




Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Polyfunctional Antibiotics Affecting Bacterial Membrane Dynamics



Anti-Infective Agents, 8(1): 3-16.

Author(s): Mark L. Nelson, Mark C. Grier, Susan E. Barbaro and Mohamed Y Ismail.

Affiliation: Paratek Pharmaceuticals, Inc., 75 Kneeland St, Boston, MA, USA.

Abstract

The β-lactam family of antibiotics, the penicillins and cephalosporins, act primarily at the level of the bacterial membrane by inhibiting membrane proteins associated with cell wall synthesis. As a family they represent some of the most clinically relevant antibiotics known, although antibiotic resistance has limited the use of older generation β-lactams, novel compounds are currently emerging from research efforts worldwide. Fortuitously, there are other families of antibiotics of peptide-derived origin and possessing polyfunctional chemical groups-compounds with complex and multiple pharmacophores with biological function- that also act at the level of the bacterial membrane. Polyfunctional antibiotics interfere with bacterial growth by direct interaction with the cell membrane lipid bilayer and its constitutive array of metabolically active enzymes and structural proteins.

Keywords:

Bacterial Membrane, β-lactam family, penicillins, cephalosporins, pharmacophores, cell membrane, lipid, enzymes.



Download Free Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 8
Issue Number: 1
First Page: 3
Last Page: 16
Page Count: 14
DOI: 10.2174/187152109787047779
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science