Antiviral Unsaturated Nucleosides

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Antiviral Unsaturated Nucleosides



Anti-Infective Agents, 7(4): 219-244.

Author(s): Dimitri Komiotis, Stella Manta, Evangelia Tsoukala and Niki Tzioumaki.

Affiliation: University of Thessaly, Department of Biochemistry&Biotechnology, Laboratory of Organic Chemistry, 26 Ploutonos Str., 41221 Larissa, Greece.

Abstract

In the search for effective, selective and nontoxic antiviral agents, a variety of nucleoside analogues have been synthesized, with different functionalities in the carbohydrate moiety. Unsaturated nucleoside analogues are recognized as an important class of biologically active compounds and appear to be prominent drugs in the management of several viral infections, including HSV, HIV, HBV, HCV and HCMV infections. Currently, unsaturated nucleoside mimetics, such as stavudine, abacavir and entecavir have been approved for the treatment of viral infections, while elvucitabine and β-L-2β- F-d4C are in clinical trials. The purpose of this review is to give an update of the recent developments on unsaturated nucleoside and nucleoside analogues, in both cyclic and acyclic forms, which possess promising therapeutic potential, mainly antiviral. It covers analogues with ring sizes from three to six and provides useful data, in the aim to enhance chemical reactivity or to study the fixation of the sugar conformation.

Keywords:

Unsaturated nucleosides, carbocyclic, exomethylene, acyclic, antiviral.



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Article Details

Volume: 7
Issue Number: 4
First Page: 219
Last Page: 244
Page Count: 26
DOI: 10.2174/187152108785908848
Price: $58
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