Aminoglycosidic Aminocyclitol Antibiotics-A Wonder, But Toxic Drugs:Developments and Clinical Implications

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


Download PDF Flyer




Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

This journal supports open access

Aims & ScopeAbstracted/Indexed in


Submit Abstracts Online Submit Manuscripts Online

View Full Editorial Board

Subscribe Purchase Articles Order Reprints


Aminoglycosidic Aminocyclitol Antibiotics-A Wonder, But Toxic Drugs:Developments and Clinical Implications



Anti-Infective Agents, 6(2): 107-117.

Author(s): M Shahid.

Affiliation: Department of Medical Microbiology,JN Medical College&Hospital, AMU Aligarh-202002, U.P.,India.

Abstract

Aminoglycosides are aminoglycosidic aminocyclitols that contain amino sugars linked to an aminocyclitol ring by glycosidic bonds. Although relatively toxic compared with other classes of antibiotics, they remain primarily useful drugs in the treatment of infections caused by gram-negative bacteria. Since the advent of streptomycin by Waksman and co-workers, a series of milestone compounds like kanamycin, gentamicin, and tobramycin were introduced for the treatment of gram-negative bacillary infections. In 1970s, the semisynthetic aminoglycosides dibekacin, amikacin, and netilmicin demonstrated the possibility of obtaining compounds active against resistant strains that had developed resistance mechanisms towards earlier aminoglycosides. However, since then, the pace of development of new aminoglycosides has markedly slowed down. This review not only provides the comprehensive accounts of the developments in aminoglycoside antibiotics, but also provides insight about the mechanism of action and resistance, current efforts to develop aminoglycoside mimetics that target RNA, and potential strategies to overcome inactivation of aminoglycosides by aminoglycoside- modifying enzymes. Some of the interesting clinical implications like natural aminoglycoside resistances typical of common pathogens, prediction of responsible aminoglycoside-modifying enzyme from antibiogram data, and the use of liposomal-encapsulated aminoglycosides to increase the therapeutic index have also been discussed.

Keywords:

Aminoglycosides, aminoglycosidic aminocyclitols, aminoglycoside-modifying enzymes, mechanism, mimetics, resistance, semisynthetic aminoglycosides.



Purchase Online Order Reprints Order Eprints Rights and Permissions




Article Details

Volume: 6
Issue Number: 2
First Page: 107
Last Page: 117
Page Count: 11
DOI: 10.2174/187152107780361643
Price: $58
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2016 Bentham Science