Extended-Spectrum Cephalosporinases in Enterobacteriaceae

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 15, 2 Issues, 2017

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Extended-Spectrum Cephalosporinases in Enterobacteriaceae

Anti-Infective Agents, 6(1): 71-82.

Author(s): Hedi Mammeri and Patrice Nordmann.

Affiliation: Service de Bacteriologie-Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin-Bicetre, France.


Extended-spectrum AmpC β-lactamases are derived from chromosomal cephalosporinases by amino acid deletion, insertion and replacement. These structural changes are responsible for an increased catalytic efficiency against extended- spectrum cephalosporins, such as ceftazidime, cefotaxime, cefepime, and cefpirome. An overview of the molecular and biochemical characterization of these identified β-lactamases in Enterobacteriaceae is provided. The structural modifications that account for the broadening substrate specificity and the phenotypes of resistance of the clinical isolates are detailed.


ESAC, extended-spectrum cephalosporinase, cefepime, ceftazidime.

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Article Details

Volume: 6
Issue Number: 1
First Page: 71
Last Page: 82
Page Count: 12
DOI: 10.2174/187152107779314133

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