Mechanism of Action and Potential for Use of Tea Catechin as an Antiinfective Agent

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Mechanism of Action and Potential for Use of Tea Catechin as an Antiinfective Agent



Anti-Infective Agents, 6(1): 57-62.

Author(s): Tadakatsu Shimamura, Wei-Hua Zhao and Zhi-Qing Hu.

Affiliation: Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai,Shinagawa-ku, Tokyo 142-8555, Japan.

Abstract

“Drinking several cups of green tea a day keeps the doctor away” is clearly an overstatement. However, extensive research has revealed that the predominant catechin from tea (Camellia sinensis), epigallocatechin gallate (EGCg), has significant medicinal and health-promoting properties. This review summarizes what is presently known about the antimicrobial properties of EGCg, with a particular focus on the synergistic relationship between EGCg and β-lactams in the inhibition of methicillin-resistant Staphylococcus aureus (MRSA). The mechanisms of action and prospects for use of tea catechins such as EGCg as an anti-infective agent are discussed.

Keywords:

Tea, catechins, EGCg, polyphenols, flavanols, antimicrobial agents, β-lactams, MRSA.



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Article Details

Volume: 6
Issue Number: 1
First Page: 57
Last Page: 62
Page Count: 6
DOI: 10.2174/187152107779314124
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