Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 14, 2 Issues, 2016

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics

Anti-Infective Agents, 5(3): 255-271.

Author(s): Jie Li and Cheng-Wei Tom Chang.

Affiliation: Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA.


Aminoglycosides represent an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their clinical efficacy and prompted the renewed interest in the study of resistant mechanisms as well as the development of novel aminoglycoside antibiotics. This review will focus on the latest development in the design and synthesis of novel aminoglycoside derivatives.


Tobramycin Derivatives, O-5 Glycosylated Neomycin, methicillin resistant S aureus (MRSA), Conformational constrained neomycin, RNA targets, Kanamycin, glycosylation.

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Article Details

Volume: 5
Issue Number: 3
First Page: 255
Last Page: 271
Page Count: 17
DOI: 10.2174/187152106777697844
Price: $58
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