Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Effect of Electronegative Groups on the Antimicrobial Activity of 3, 5- Disubstituted Thiazolidine-2,4-diones



Anti-Infective Agents, 12(1): 112-119.

Author(s): Radhe S. Bahare and Swastika Ganguly.

Affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India.

Abstract

A series of 30 novel thiazolidine-2,4-diones (3a-o, 4a-o) have been synthesized and evaluated for their antibacterial and antifungal activities against pathogenic microorganisms Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger using two fold serial dilution method.. In the present study thiazolidine- 2,4-dione derivatives has been substituted with electronegative groups at the 3rd and the 5th position. Some of the compounds have shown promising antimicrobial activity.

Keywords:

Antibacterials, antifungal, MIC, synthesis, thiazolidine-2, 4-dione, two fold serial dilution method.



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Article Details

Volume: 12
Issue Number: 1
First Page: 112
Last Page: 119
Page Count: 8
DOI: 10.2174/221135251201140102003059
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