An Update on the Antifungal Activities of Lactoferrin: New Promising Applications in Diagnostic, Therapeutics and Biotechnology

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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An Update on the Antifungal Activities of Lactoferrin: New Promising Applications in Diagnostic, Therapeutics and Biotechnology



Anti-Infective Agents, 11(2): 155-158.

Author(s): Francesco Giansanti, Loris Leboffe, Ilaria D’Elia and Giovanni Antonini.

Affiliation: Interdepartmental Laboratory of Electronic Microscopy, ‘Roma-Tre’ University, I-00146 Roma, Italy.

Abstract

Lactoferrin is an iron binding protein belonging to the transferrin superfamily. Its main function is the protection towards infections. In a previous article (Leboffe et al., Anti-Infective Agents in Medicinal Chemistry, 2009), we have reviewed the antifungal and antiparasitic activity of lactoferrin. In the present updated review we focused the attention on the newly discovered antifungal properties of lactoferrin and its derived peptides in clinical, diagnostic and biotechnological applications. In particular, we discuss the new findings on diagnosis of fungal infections utilizing Lf and on emerging pharmacological treatments exploiting combined effects of Lf and classical antifungal drugs. We also reported recent studies on the use of Lf antifungal activity for food and beverage preservation. These new properties have found applications both “in vitro” and “in vivo”, opening new scenarios about the use of this protein as an antinfective agent both in translational medicine and biotechnology.

Keywords:

Antifungal, antimicrobial peptides, antiparasitic, biotechnological applications, diagnostics, diagnostics, iron, lactoferrin, mycosis, natural immunity, parasitic diseases, therapeutics, translational medicine.



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Article Details

Volume: 11
Issue Number: 2
First Page: 155
Last Page: 158
Page Count: 4
DOI: 10.2174/2211352511311020009
Price: $58
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