Synthesis and Antitubercular Activity of a Series of Thiazole Derivatives

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)

Volume 15, 2 Issues, 2017

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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Synthesis and Antitubercular Activity of a Series of Thiazole Derivatives

Anti-Infective Agents, 12(2): 149-158.

Author(s): Mahesh Chhabria, Shailesh Patel, Sandeep Dholakia, Hardik Mistry and Sweta Patel.

Affiliation: Department of Pharmaceutical Chemistry, L. M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat 380 009, India.


Tuberculosis (TB) is of increasing concern due to the recent emergence and spread of MDR-TB, XDR-TB, TDR-TB and HIV/AIDS pandemic. There is urgent need for novel antitubercular agents which can shorten the treatment duration. Based on isosteric replacement and 3D structural similarity between Linezolid, an oxazolidine antimycobacterial agent, we have designed novel 4-amino-3,5-di(substituted)thiazolin-2(3H)thione/ones, synthesized and evaluated for their antimycobacterial activity on Mycobacterium tuberculosis H37Rv strain. Some of the compounds exhibited potent antimycobacterial activity with MIC values in the range of 1-2 µg/mL. Active compounds were further screened against MDR-TB and XDR-TB strain and found to exhibit promising in vitro activity.


Antimycobacterial activity, MDR-TB, thiazolin-thione/ones, XDR-TB.

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Article Details

Volume: 12
Issue Number: 2
First Page: 149
Last Page: 158
Page Count: 10
DOI: 10.2174/22113525113119990119
Price: $58

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