Design, Synthesis and In Vitro Anti-Mycobacterial Activity of Chromene Fused Cytosine and Uracil Analogues

ISSN: 2211-3533 (Online)
ISSN: 2211-3525 (Print)


Volume 14, 2 Issues, 2016


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Anti-Infective Agents

Formerly: Anti-Infective Agents in Medicinal Chemistry

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Design, Synthesis and In Vitro Anti-Mycobacterial Activity of Chromene Fused Cytosine and Uracil Analogues



Anti-Infective Agents, 11(1): 42-48.

Author(s): Nimesh R. Kamdar, Dhaval D. Haveliwala, Prashant T. Mistry and Saurabh K Patel.

Affiliation: Department of Chemistry, Veer Narmad South Gujarat University, Surat-395 007 Gujarat, India.

Abstract

A series of chromene fused cytosine and uracil were prepared by the condensation of thiourea or carbon disulphide with 2-amino-7,7-dimethyl-5-oxo-4-(substituted phenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile. The newly synthesized compounds were characterized by IR, 1H-NMR, Elemental analysis and some representative 13C-NMR and Mass spectra. All the title compounds were evaluated for antitubercular and antimicrobial activities against various mycobacterial, bacterial and fungal strains. Some of the compounds have shown promising antimicrobial and antitubercular activity while others were inactive.

Keywords:

Antimicrobial activity, antitubercular activity, chromene, fused cytosine, fused uracil.



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Article Details

Volume: 11
Issue Number: 1
First Page: 42
Last Page: 48
Page Count: 7
DOI: 10.2174/22113626130105
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