Apoptosis and Apoptosis-Based Therapy in Lung Cancer

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 17, 14 Issues, 2017

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Michelle Prudhomme
Institut de Chimie de Clermont-Ferrand
Université Clermont Auvergne

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Apoptosis and Apoptosis-Based Therapy in Lung Cancer

Anti-Cancer Agents in Medicinal Chemistry, 9(9): 952-957.

Author(s): Cheng-Xiong Xu, Hua Jin and Myung-Haing Cho.

Affiliation: Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.


Apoptosis is natural process in the development and maintenance of multicellular organisms. However, tumor cells often have faulty apoptotic pathways. The defects of apoptosis are partially caused by mutation and aberrant expression of apoptotic proteins. The apoptosis inactivation is implicated with both tumorigenesis and drug resistance. In addition, as compared to small-cell lung cancers, non-small cell lung cancers are less sensitive to radiation treatment or chemotherapy. Therefore, understanding the mechanisms of apoptosis induction in lung cancer cells is very important for anti-lung cancer drug development and lung cancer therapy. In this review, we discussed about the apoptosis mechanisms and altered apoptosis regulators expression and gene mutation in lung cancer.


Lung cancer, apoptosis, anticancer agent.

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Article Details

Volume: 9
Issue Number: 9
First Page: 952
Last Page: 957
Page Count: 6
DOI: 10.2174/187152009789377682
Price: $58

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