Regulation and Importance of the PI3K/Akt/mTOR Signaling Pathway in Hematologic Malignancies

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Regulation and Importance of the PI3K/Akt/mTOR Signaling Pathway in Hematologic Malignancies



Anti-Cancer Agents in Medicinal Chemistry, 9(9): 1024-1038.

Author(s): Kiyotaka Kawauchi, Toshie Ogasawara, Masako Yasuyama, Kuniaki Otsuka and Osamu Yamada.

Affiliation: 2-1-10 Nishiogu Arakawa-ku, Tokyo, 116-8567, Japan.

Abstract

Phosphatidylinositol 3-kinase (PI3K), a heterodimeric lipid kinase, is a key enzyme in signal transduction from various stimuli to downstream pathways that elicit diverse responses involving growth, proliferation, survival, differentiation, and metabolism in many cellular systems. Activated PI3K generates phosphatidylinositol-3,4,5-triphosphate, which recruits phosphatidylinositol-dependent kinase 1 (PDK1) and Akt serine/threonine kinase at the plasma membrane, resulting in activation of Akt. In turn, Akt activates multiple downstream targets, most notably the mTOR pathway. There is abundant evidence implicating the PI3K/Akt/mTOR pathway in the development and progression of a variety of tumors including hematologic neoplasms. Therefore, this pathway is considered a critical target for cancer therapy. We review the regulatory mechanisms of the PI3K/Akt/mTOR signaling pathway and the role of this pathway in oncogenesis of hematological malignancies.

Keywords:

PI3K, Akt, mTOR, hematologic malignancies.



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Article Details

Volume: 9
Issue Number: 9
First Page: 1024
Last Page: 1038
Page Count: 15
DOI: 10.2174/187152009789377772
Price: $58
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