Can the Status of the Breast and Ovarian Cancer Susceptibility Gene 1 Product (BRCA1) Predict Response to Taxane-Based Cancer Therapy?

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Can the Status of the Breast and Ovarian Cancer Susceptibility Gene 1 Product (BRCA1) Predict Response to Taxane-Based Cancer Therapy?



Anti-Cancer Agents in Medicinal Chemistry, 9(5): 543-549.

Author(s): J. Thomas DeLigio, Aneliya Velkova, Diego A.R. Zorio and Alvaro NA Monteiro.

Affiliation: H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Abstract

Taxanes (paclitaxel and docetaxel) are currently used to treat ovarian, breast, lung, and head and neck cancers. Despite its clinical success taxane-based treatment could be significantly improved by identifying those patients whose tumors are more likely to present a clinical response. In this mini-review we discuss the accumulating evidence indicating that the breast and ovarian cancer susceptibility gene product BRCA1 mediates cellular response to taxanes. We review data from in vitro, animal, and clinical studies, and discuss them in context of response to therapy. We argue that levels of BRCA1 in tumors may provide a predictive marker for the response to treatment with taxanes. In addition, the study of the role of BRCA1 in the mechanism of action of taxanes might reveal alternative approaches to avoid resistance.

Keywords:

Taxol, taxane, BRCA1, cancer, biomarker, microtubule, tubulin, chemotherapy.



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Article Details

Volume: 9
Issue Number: 5
First Page: 543
Last Page: 549
Page Count: 7
DOI: 10.2174/187152009788451798
Price: $58
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