Tripentones: A Promising Series of Potent Anti-Cancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Tripentones: A Promising Series of Potent Anti-Cancer Agents



Anti-Cancer Agents in Medicinal Chemistry, 9(4): 369-380.

Author(s): Christophe Rochais, Patrick Dallemagne and Sylvain Rault.

Affiliation: CERMN UPRES EA 4258–FR CNRS 3038 INC3M, UFR des Sciences Pharmaceutiques–Universite de Caen Basse-Normandie, Bd Becquerel 14032 Caen Cedex, France.

Abstract

The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol- 9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.

Keywords:

Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer.



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Article Details

Volume: 9
Issue Number: 4
First Page: 369
Last Page: 380
Page Count: 12
DOI: 10.2174/1871520610909040369
Price: $58
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