Antimitotic Chalcones and Related Compounds as Inhibitors of Tubulin Assembly

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Antimitotic Chalcones and Related Compounds as Inhibitors of Tubulin Assembly

Anti-Cancer Agents in Medicinal Chemistry, 9(3): 336-347.

Author(s): Sylvie Ducki.

Affiliation: Laboratoire de Chimie des Heterocycles et des Glucides, ENSCCF, Clermont Universite, 24 avenue des Landais, 63174 Aubiere, France.


The development of chalcones as antimitotic agents has led to the design of other analogues able to interact with tubulin and inhibit its assembly into microtubules. This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents.


Chalcone, tubulin, microtubule, antimitotic, cytotoxic.

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Article Details

Volume: 9
Issue Number: 3
First Page: 336
Last Page: 347
Page Count: 12
DOI: 10.2174/1871520610909030336
Price: $58

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