Quantification Techniques and Biodistribution of Semiconductor Quantum Dots

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Quantification Techniques and Biodistribution of Semiconductor Quantum Dots



Anti-Cancer Agents in Medicinal Chemistry, 9(3): 295-303.

Author(s): Emilie Pic, Lina Bezdetnaya, Francois Guillemin and Frederic Marchal.

Affiliation: CRAN, Nancy-University, CNRS, Centre Alexis Vautrin, avenue de Bourgogne, 54511 Vandoeuvreles- Nancy Cedex, France.

Abstract

Quantum dots (QDs) are fluorescent inorganic nanocrystals with advantageous optical properties, which have been applied for biomedical purposes including imaging, diagnostic, drug delivery or therapy. Potential toxicity of QDs remains the major barrier to clinical translation, and as such the precise analysis of in vivo QDs distribution and pharmacokinetics is of major importance. Biodistribution studies in animal models are, however, sparse. The present review provides in a first lieu a summary of different techniques, which are currently used for relative quantification of QDs in vivo or their absolute quantification ex vivo. Fluorescence and radioactivity based techniques along with mass-spectrometry detection at the elementary level are addressed in this review. We further introduce biodistribution studies in animal models and discuss the possibilities to modify quantum dots biodistribution in function of different injection ways.

Keywords:

Quantum dots, in vivo, detection, fluorescence, radioactivity, mass-spectroscopy, biodistribution.



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Article Details

Volume: 9
Issue Number: 3
First Page: 295
Last Page: 303
Page Count: 9
DOI: 10.2174/1871520610909030295
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