Marine Macrolides, a Promising Source of Antitumor Compounds

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Marine Macrolides, a Promising Source of Antitumor Compounds



Anti-Cancer Agents in Medicinal Chemistry, 9(2): 122-137.

Author(s): Jose G. Napolitano, Antonio H. Daranas, Manuel Norte and Jose J Fernandez.

Affiliation: Instituto Universitario de Bioorganica “Antonio Gonzalez”, Astrofisico Fco. Sanchez 2, Universidad de La Laguna, La Laguna 38206, Canary Islands, Spain.

Abstract

Marine organisms have attracted scientific community as a rich source of natural products with unusual structural features and remarkable biological activities. Marine macrolides are a prominent class of natural products characterized by a highly oxygenated polyene backbone containing a macrocyclic lactone as a conformational constraint. Many marine macrolides possess outstanding cell growth antiproliferative properties, making them valuable molecular probes for the investigation of biochemical pathways and promising lead compounds for the development of new antitumor chemotherapeutic agents. In the present review we intend to focus on marine macrolides with potent cytotoxic activity that could be exploited in cancer research and therapy, along with those macrolides currently in clinical trials and/or preclinical development.

Keywords:

Marine macrolides, antitumor agents, natural products, cytotoxicity, cancer.



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Article Details

Volume: 9
Issue Number: 2
First Page: 122
Last Page: 137
Page Count: 16
DOI: 10.2174/187152009787313800
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