Targeting Prostate Cancer Stem Cells

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Targeting Prostate Cancer Stem Cells



Anti-Cancer Agents in Medicinal Chemistry, 9(10): 1105-1113.

Author(s): Francesco Crea, Lesley A. Mathews, William L. Farrar and Elaine M Hurt.

Affiliation: Laboratory of Cancer Prevention, NCI-Frederick, 1050 Boyles Street, Building 560, Room 21-81, USA.

Abstract

Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

Keywords:

Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin.



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Article Details

Volume: 9
Issue Number: 10
First Page: 1105
Last Page: 1113
Page Count: 9
DOI: 10.2174/187152009789735053
Price: $58
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