Cell Cycle Control by the CDC25 Phosphatases

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Cell Cycle Control by the CDC25 Phosphatases



Anti-Cancer Agents in Medicinal Chemistry, 8(8): 818-824.

Author(s): Bernadette Aressy and Bernard Ducommun.

Affiliation: University of Toulouse, CNRS - UMR5088 and IFR109 “Institut d'Exploration Fonctionnelle des Genomes”, 118 route de Narbonne, 31062 TOULOUSE, France.

Abstract

Cell division cycle 25 (CDC25) phosphatases are key actors in eukaryotic cell cycle control. They are responsible for the dephosphorylations that activate the cyclin-dependent kinases (CDK) at specific stages of the cell cycle. Human CDC25A, CDC25B and CDC25C are also central targets and regulators of the G2/M checkpoint mechanisms activated in response to DNA injury. The expression and activity of these enzymes is finely regulated by multiple mechanisms including post-translational modifications, interactions with regulatory partners, control of their intracellular localization, and cell cycle-regulated degradation. Altered expression of these phosphatases is associated with checkpoint bypass and genetic instability. Accordingly, increased expression of CDC25A and CDC25B is found in many high-grade tumors and is correlated with poor prognosis in human cancers. This review summarizes our current knowledge within this domain and discusses the data that support therapeutic strategies targeting CDC25 activity in the treatment of cancer.

Keywords:

Cell, CDC25 Phosphatases, eukaryotic cell, cyclin-dependent kinases (CDK), DNA injury, genetic instability, human cancers.



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Article Details

Volume: 8
Issue Number: 8
First Page: 818
Last Page: 824
Page Count: 7
DOI: 10.2174/187152008786847756
Price: $58
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