Dimeric Approaches to Anti-Cancer Chemotherapeutics

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)

Volume 16, 12 Issues, 2016

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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex

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Dimeric Approaches to Anti-Cancer Chemotherapeutics

Anti-Cancer Agents in Medicinal Chemistry, 8(7): 807-816.

Author(s): M. K. Hadden and B SJ Blagg.

Affiliation: Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, KS 66045-7563, USA.


Numerous proteins responsible for cell proliferation and differentiation exist either as hetero or homodimers or become activated through dimerization as a key step in their respective signaling cascade. Many of these proteins have been identified as major components in oncogenic signaling pathways and have become popular targets for the development of anti-tumor agents. For this reason, bivalent anti-cancer drugs that could potentially interact with each monomer of a dimeric protein target have been developed. This review provides a brief background on prevalent dimeric drug targets within the anti-cancer field and focuses mainly on dimeric natural product and synthetic cancer chemotherapeutics.


Anti-cancer, dimer, natural product dimers, synthetic dimers, bisintercalators.

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Article Details

Volume: 8
Issue Number: 7
First Page: 807
Last Page: 816
Page Count: 10
DOI: 10.2174/187152008785914743
Price: $58

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