Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents



Anti-Cancer Agents in Medicinal Chemistry, 8(6): 698-704.

Author(s): Yingjie Zhang and Wenfang Xu.

Affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong, China.

Abstract

The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster spindles. Compared with the traditional chemotherapeutic agents (taxanes, vinca alkaloids), KSP inhibitors (KSPi) will not lead to the neuropathic side effects, so KSP has become a novel and an attractive anticancer target. Accordingly, more and more interest has been focused on the development of high effective and selective KSPi. This review will focus on some kinds of KSPi on the basis of introducing structure and function of KSP.

Keywords:

Kinesin, KSP, Uncompetitive Inhibitor, Competitive Inhibitor, Allosteric Inhibitor.



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Article Details

Volume: 8
Issue Number: 6
First Page: 698
Last Page: 704
Page Count: 7
DOI: 10.2174/187152008785133119
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