Bacteriochlorophyll a and Its Derivatives: Chemistry and Perspectives for Cancer Therapy

ISSN: 1875-5992 (Online)
ISSN: 1871-5206 (Print)


Volume 16, 12 Issues, 2016


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Anti-Cancer Agents in Medicinal Chemistry

Formerly: Current Medicinal Chemistry - Anti-Cancer Agents

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  • 27th of 59 in Chemistry, Medicinal

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Editor-in-Chief:
Michelle Prudhomme
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France


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Bacteriochlorophyll a and Its Derivatives: Chemistry and Perspectives for Cancer Therapy



Anti-Cancer Agents in Medicinal Chemistry, 8(6): 683-697.

Author(s): Mikhail A. Grin, Andrey F. Mironov and Alexander A Shtil.

Affiliation: Lomonosov Moscow Academy of Fine Chemical Technology, 86 Vernadsky Avenue, Moscow 119571, Russian Federation.

Abstract

The review summarizes the chemistry of the third generation of photosensitizers, namely, the derivatives of natural bacteriochlorophyll a for photodynamic treatment of cancer. The compounds of this class strongly absorb light at λ=770-850 nm. This unique property opens new therapeutic opportunities due to deeper tissue penetration of light, thereby increasing the photodamage for tumor eradication. Analyzed are the modifications of bacteriochlorophyll a that improve physico-chemical characteristics of compounds and enhance accumulation in tumors. Focusing on the delivery of photosensitizers to the tumor site and to specific intracellular compartments, we describe the conjugates of bacteriochlorophyll a derivatives with carbohydrate and protein carriers. Boronated bacteriochlorins can be used in both photodynamic and boron neutron capture therapy.

Keywords:

Cancer Therapy, Bacteriochlorophyll a, photosensitizers, photodynamic treatment, tumor eradication, boron neutron capture therapy.



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Article Details

Volume: 8
Issue Number: 6
First Page: 683
Last Page: 697
Page Count: 15
DOI: 10.2174/187152008785133128
Price: $58
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